Mitochondrial protein acetylation regulates metabolism
نویسندگان
چکیده
منابع مشابه
Mitochondrial protein acetylation regulates metabolism.
Changes in cellular nutrient availability or energy status induce global changes in mitochondrial protein acetylation. Over one-third of all proteins in the mitochondria are acetylated, of which the majority are involved in some aspect of energy metabolism. Mitochondrial protein acetylation is regulated by SIRT3 (sirtuin 3), a member of the sirtuin family of NAD+-dependent protein deacetylases ...
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Calorie restriction (CR) increases lifespan in organisms ranging from budding yeast through mammals. Mitochondrial adaptation represents a key component of the response to CR. Molecular mechanisms underlying this adaptation are largely unknown. Here we show that lysine acetylation of mitochondrial proteins is altered during CR in a tissue-specific fashion. Via large-scale mass spectrometry scre...
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ژورنال
عنوان ژورنال: Essays in Biochemistry
سال: 2012
ISSN: 0071-1365,1744-1358
DOI: 10.1042/bse0520023